National Heart, Lung, and Blood Institute (2012 31 July Updated). What are they? Low PDW: Learn More. Because the PDW is part of a complete blood count, it may be ordered for a wide variety of reasons.

Please consult your healthcare provider.

Each component of the clotting process must be present, activated at the right time, and functioning properly for adequate clotting. Platelets recently released from bone marrow tend to be larger and to contain more RNA than older, smaller platelets, which discard their endoplasmic reticulum as they mature. If your condition is mild and your platelet count is only slightly low, you may not require any treatment. It provides a common language to unambiguously identify things you can measure or observe that enables the exchange and aggregation of clinical results for care delivery, outcomes management, and research. Available online at https://www.nhlbi.nih.gov/health-topics/thrombocytopenia. Davis Company, Philadelphia, PA [18th Edition]. If my platelet count is abnormal, what follow-up tests might my healthcare practitioner order? Mosby's Diagnostic and Laboratory Test Reference 12th Edition: Mosby, Inc., Saint Louis, MO. Inherited disorders caused by genetic defects in platelets include Glanzmann's Thrombasthenia, Bernard-Soulier disease, Chediak-Higashi syndrome, Wiskott-Aldrich syndrome, May-Hegglin syndrome, and Down syndrome. Reference ranges are the values expected for a healthy person. An example is thrombocythemia, also called primary or essential thrombocythemia, a rare myeloproliferative disorder in which the bone marrow produces an extremely high number of platelets. AACC, ASCLS and its Service volunteers disclaim any liability arising out of your use of this Service or for any adverse outcome. 2007. The rest of the blood parameters would be required for a specific diagnosis. Medscape. Platelet distribution width Auto (Bld) [Entitic vol], Platelet distribution width (Bld) [Ratio], Platelet mean volume Auto (Bld) [Entitic vol], Platelet mean volume Rees-Ecker (Bld) [Entitic vol], Clump together (aggregate) with other platelets, Release chemical compounds that stimulate aggregation of other platelets, To screen for or diagnose various diseases and conditions that can cause problems with blood clot formation. However, these individuals typically do not experience any signs or symptoms related to this condition. Pp 732-734. The test is included in a complete blood count (CBC), a panel of tests often performed as part of a general health exam. Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer? (July 17, 2010) Mayo Clinic. Bowersox, Natalie A MD (2016 September 30, Updated). IPF is the percentage of immature platelets (also called reticulated platelets) circulating in the blood. These calculations can give your healthcare practitioner additional information about your platelets and the cause of a high or low platelet count.

The Service is provided free of charge by the American Society for Clinical Laboratory Science, which is one of many laboratory organizations that supports Lab Tests Online. This test result may indicated that there is an immune disorder present or that there is a rare inherited disorder like Bernard-Soulier disease which is affecting the individual. F.A. A second test may be ordered in this circumstance with an anticoagulant added to prevent clumping so that the sample can be properly studied. (Aug 1, 2010) National Heart, Lung and Blood Institute. Accessed 07/18/15. This may also be an indication that there is a disorder present which is affecting the bone marrow and how it is able to produce platelets. Thrombocytopenia. Pagana, Kathleen D. & Pagana, Timothy J. If you have a very low platelet count, you may be given platelets through a transfusion. Values that are outside expected ranges can provide clues to help identify possible conditions or diseases.

How is Thrombocytopenia Treated? There are numerous younger platelets and numerous older platelets in the same sample. Larger platelets are usually younger platelets that have been released earlier than normal from the bone marrow, while smaller platelets may be older and have been in circulation for a few days. For platelet width, the general rule is that larger platelets are generally younger, while smaller platelets have been around for a few days. Heparin-induced thrombocytopenia (HIT) results in low platelets when you are or have been treated with heparin and you develop an antibody. Other uses are being studied and the test's ultimate clinical utility has not yet been well determined. If bone marrow disorders are suspected, however, it may also be ordered. Thomas, Clayton L., Editor (1997). Individuals who have this condition may be at risk of excessive clotting (thrombosis) due to the excess number of platelets but may also experience bleeding problems due to platelets not functioning normally. The reference ranges1 provided here represent a theoretical guideline that should not be used to interpret your test results.
What does PDW mean in a blood test? American Society of Hematology. This disorder is often associated with a mutation in the gene called JAK2. Laboratory test results are not meaningful by themselves. Lab test results including platelet count and IPF can also be used to help determine if you need a platelet transfusion and to help monitor bone marrow recovery, such as after a bone marrow transplant.

(2013 October). Certain drugs and cancers can also cause this result. Lab Tests Online is an award-winning patient education website offering information on laboratory tests. If the PDW blood test has abnormal results and if there isn’t a known cause for them, then a doctor may choose to perform additional follow-up tests in an attempt to confirm a diagnosis. Your platelet count is interpreted by your healthcare practitioner within the context of other tests that you have had done (e.g., CBC) as well as other factors, such as your medical history. It is one of the values reported when blood is evaluated using an automated instrument. Your questions will be answered by a laboratory scientist as part of a voluntary service provided by one of our partners, American Society for Clinical Laboratory Science. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883212/. The CBC blood test will include a measurement of platelet distribution width, which is how the PDW blood test results will be measured. Available online at https://imagebank.hematology.org/image/60931/giant-platelets?type=atlas. However, you may have no signs or symptoms if you have increased platelets, so the condition may be found only when a platelet count is done as part of a health exam or for another condition. Taber's Cyclopedic Medical Dictionary. Examination of the Percentage of Immature Platelet Fraction in Term and Preterm Infants at Birth.

Johns Hopkins Medicine. PDW is a more specific marker of platelet activation, since it does not increase during simple platelet swelling.

There are numerous younger platelets and numerous older platelets in the same sample. Platelets are produced in the bone marrow and are normally not released into the bloodstream until they have matured. Pagana K, Pagana T. Mosby's Manual of Diagnostic and Laboratory Tests. This is usually the result of an existing condition (also called secondary or reactive thrombocytosis), such as: Some conditions may cause a temporary increased platelet count. Essential Thrombocythemia. When a doctor requires a platelet count, then a complete blood count may be ordered. These may be seen in certain disorders such as immune thrombocytopenic purpura or in rare inherited disorders such as Bernard-Soulier disease. If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.
Riley R, et.al. This is a reason why so few reference ranges are provided on this site.


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